The Neosho Central Campus, formerly known as Jefferson Street Campus, is dedicated to providing a safe place for students to thrive in an academic setting that is rigorous, interactive and meaningful. It has successfully served at-risk students since the 1996-1997 school year. Students who are at-risk of graduating are identified and referred through teachers, counselors, and administration of Neosho's main campus. Central Campus is home to five certified teachers who, with great heart and dedication, meet the educational needs of 50 students at any given time. Vacated seats on the Central Campus are filled immediately, as there is a waiting list. The enrollment process requires guardian and student participation with the understanding that students will experience stricter discipline policies along with higher attendance and grade expectations.

In the 2023-2024 school year, the program was moved from Jefferson Street, located at 115 W. Brook St., Neosho, to the former Central Elementary building, located at 301 Big Spring Drive, Neosho. The building was renamed to Central Campus, honoring both past and present students. 

The Central Campus provides an alternative academic setting featuring innovative approaches to remediation and enrichment. Small class sizes allow teachers to individualize instruction, addressing weaknesses where they may exist and offering accelerated curriculum to bolster strengths. Instructors draw on their creativity to reveal the relevance of coursework in students’ practical lives, design project-based activities that actively engage students in meaningful learning, and work collaboratively to draw cross-curricular connections between subjects.

Scheduling is also customized to promote academic success. Students attend the same four, 90-minute blocks each day over the course of a quarter-long term, approximately nine weeks. Extended class time maximizes opportunities for instruction and guided practice. At the end of each term, students may earn a half credit for each course for a total of two credits. This means they can earn a total of eight credits from August to May, one more than at the traditional high school. This approach allows students to focus intently on four subjects at a time, earn credits quickly and incrementally and reacquire credits they may have failed to earn in the past.